human SPAG6 shRNA silencing AAV

Name
AAV-h-SPAG6-shRNA

Cat No
shAAV-224069

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SPAG6.

shAAV-224069

AAV-h-SPAG6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SPAG6 (sperm associated antigen 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CT141; pf16; Repro-SA-1

Description (Vector)

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

9576

Gene Name (Vector)

sperm associated antigen 6

Gene Symbol

SPAG6

HGNC ID

HGNC:11215

ORF Size (aa)

1377

ORF Size (bp)

1377 bp

RefSeq ID

NM_012443

RefSeq Synonyms

NM_172242, NM_012443, NM_001253855, NM_001253854, BC030585,

Species

human

UniGene ID

Hs.655170

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.