human SPAG11B shRNA silencing AAV

Name
AAV-h-SPAG11B-shRNA

Cat No
shAAV-224062

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SPAG11B.

shAAV-224062

AAV-h-SPAG11B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SPAG11B (sperm associated antigen 11B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EDDM2B; EP2; EP2C; EP2D; HE2; HE2C; SPAG11

Description (Vector)

SPAG11B encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined.

Gene ID

10407

Gene Name (Vector)

sperm associated antigen 11B

Gene Symbol

SPAG11B

HGNC ID

HGNC:14534

ORF Size (aa)

402

RefSeq ID

NM_058206

RefSeq Synonyms

NM_058207, NM_058206, NM_058203, NM_058202, NM_058201, NM_058200, NM_016512, BC160085,

Species

human

UniGene ID

Hs.2717

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.