human SPACA1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SPACA1.
shAAV-224056
AAV-h-SPACA1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SPACA1 (sperm acrosome associated 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SAMP32
Description (Vector)
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively.
Gene ID
81833
Gene Name (Vector)
sperm acrosome associated 1
Gene Symbol
SPACA1
HGNC ID
HGNC:14967
ORF Size (aa)
885
RefSeq ID
NM_030960
RefSeq Synonyms
NM_030960, BC029488,
Species
human
UniGene ID
Hs.161241
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.