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human SORL1 shRNA silencing AAV

Name 
AAV-h-SORL1-shRNA
Cat No 
shAAV-223999
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SORL1.

shAAV-223999
AAV-h-SORL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SORL1 (sortilin related receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C11orf32; gp250; LDLR relative with 11 ligand-binding repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; LRP9; mosaic protein LR11; SORLA; SorLA-1; sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; sorting protein-related receptor containing LDLR class A repeats
Description (eCommerce)
Sortilin-related receptor (SORL1) is a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. SORL1 also contains fibronectin type III repeats and an epidermal growth factor repeat. SORL1 is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting [taken from NCBI Entrez Gene (Gene ID: 6653)].
Description (Vector)
SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.
Gene ID
6653
Gene Name (eCommerce)
sortilin related receptor 1
Gene Name (Vector)
sortilin related receptor 1
Gene Symbol
SORL1
HGNC ID
HGNC:11185
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6645
ORF Size (bp)
6645 bp
Protein Name (eCommerce)
Sortilin-related receptor
RefSeq ID
NM_003105
RefSeq Synonyms
NM_003105, BC137171,
Research Areas
Alzheimer's Disease,Golgi Apparatus,Neurobiology,Neurodegeneration,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology,cell_biology,neurobiology
Species
human
Target Sentence
Sortilin-related receptor (SORL1) is a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. SORL1 also contains fibronectin type III repeats and an epidermal growth factor repeat. SORL1 is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting [taken from NCBI Entrez Gene (Gene ID: 6653)].
UniGene ID
Hs.368592
UniProt ID (eCommerce)
Q92673

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.