human SOCS3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SOCS3.
shAAV-223975
AAV-h-SOCS3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SOCS3 (suppressor of cytokine signaling 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3
Description (Vector)
SOCS3 encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Gene ID
9021
Gene Name (Vector)
suppressor of cytokine signaling 3
Gene Symbol
SOCS3
HGNC ID
HGNC:19391
ORF Size (aa)
678
RefSeq ID
NM_003955
RefSeq Synonyms
NM_003955, BC060858,
Species
human
UniGene ID
Hs.527973
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.