human SOCS1 shRNA silencing AAV

Name
AAV-h-SOCS1-shRNA

Cat No
shAAV-223973

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SOCS1.

shAAV-223973

AAV-h-SOCS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SOCS1 (suppressor of cytokine signaling 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3

Description (Vector)

SOCS1 encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Gene ID

8651

Gene Name (Vector)

suppressor of cytokine signaling 1

Gene Symbol

SOCS1

HGNC ID

HGNC:19383

ORF Size (aa)

636

RefSeq ID

NM_003745

RefSeq Synonyms

NM_003745, BC153088, BC148542,

Species

human

UniGene ID

Hs.50640

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.