human SMOC2 shRNA silencing AAV

Name
AAV-h-SMOC2-shRNA

Cat No
shAAV-223764

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SMOC2.

shAAV-223764

AAV-h-SMOC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMOC2 (SPARC related modular calcium binding 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1; MST117; MSTP117; MSTP140; SMAP2

Description (Vector)

SMOC2 encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants.

Gene ID

64094

Gene Name (Vector)

SPARC related modular calcium binding 2

Gene Symbol

SMOC2

HGNC ID

HGNC:20323

ORF Size (aa)

1341

ORF Size (bp)

1341 bp

RefSeq ID

NM_022138

RefSeq Synonyms

NM_022138, NM_001166412, BC047583, BC028420,

Species

human

UniGene ID

Hs.487200

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.