human SMG6 shRNA silencing AAV

Name
AAV-h-SMG6-shRNA

Cat No
shAAV-223754

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SMG6.

shAAV-223754

AAV-h-SMG6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMG6 (smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C17orf31; EST1A; KIAA0732; SMG-6;

Description (Vector)

SMG6 encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of this gene also participates in the nonsense-mediated mRNA decay (NMD) pathway. The encoded protein contains two binding sites for components of the exon junction complex (EJC); interaction between the encoded protein and the EJC is necessary for NMD activity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

23293

Gene Name (Vector)

smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)

Gene Symbol

SMG6

HGNC ID

HGNC:17809

ORF Size (aa)

4257

ORF Size (bp)

4257 bp

RefSeq ID

NM_017575

RefSeq Synonyms

NM_017575, NM_001282326, NM_001256828, NM_001256827, NM_001170957, BC148373, BC064916,

Species

human

UniGene ID

Hs.448342

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.