human SMC4 shRNA silencing AAV

Name 
AAV-h-SMC4-shRNA
Cat No 
shAAV-223738
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SMC4.

shAAV-223738
AAV-h-SMC4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMC4 (structural maintenance of chromosomes 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAPC; CAP-C; chromosome-associated polypeptide C; hCAP-C; SMC protein 4; SMC-4; SMC4 structural maintenance of chromosomes 4-like 1; SMC4L1; structural maintenance of chromosomes protein 4; XCAP-C homolog
Description (eCommerce)
SMC (Structural maintenance of chromosomes) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex includes a heterodimer of SMC2 and SMC4 that functions to create positively supercoiled loops for chromatin condensation and metaphase chromatid shaping. A function for condensin in the DNA damage checkpoint response and gene repression has also been suggested.
Description (Vector)
Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.(supplied by OMIM, Nov 2010)
Gene ID
10051
Gene Name (eCommerce)
structural maintenance of chromosomes 4
Gene Name (Vector)
structural maintenance of chromosomes 4
Gene Symbol
SMC4
HGNC ID
HGNC:14013
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3867
ORF Size (bp)
3867 bp
Protein Name (eCommerce)
Structural maintenance of chromosomes protein 4
RefSeq ID
NM_005496
RefSeq Synonyms
NM_005496, NM_001288753, NM_001002800, BC148796, BC146370,
Research Areas
Cell Cycle,Cell Division,DNA Damage/Repair,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
SMC (Structural maintenance of chromosomes) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex includes a heterodimer of SMC2 and SMC4 that functions to create positively supercoiled loops for chromatin condensation and metaphase chromatid shaping. A function for condensin in the DNA damage checkpoint response and gene repression has also been suggested.
UniGene ID
Hs.58992
UniProt ID (eCommerce)
Q9NTJ3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.