human SMARCD2 shRNA silencing AAV

Name 
AAV-h-SMARCD2-shRNA
Cat No 
shAAV-223726
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SMARCD2.

shAAV-223726
AAV-h-SMARCD2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMARCD2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
60 kDa BRG-1/Brm-associated factor subunit B; BAF60B; BRG1-associated factor 60B; chromatin remodeling complex BAF60B subunit; CRACD2; mammalian chromatin remodeling complex BRG1-associated factor 60B; PRO2451; Rsc6p; SGD2; SWI/SNF complex 60 kDa subunit B; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; Swp73-like protein
Description (eCommerce)
The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. SMARCD2/BAF60B was isolated from a cDNA library in a search for proteins similar to mouse BAF60A which was identified as the paralog of the S. cerevisiae SWI/SNF component, SWP73.
Description (Vector)
SMARCD2 is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
6603
Gene Name (eCommerce)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Gene Name (Vector)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Gene Symbol
SMARCD2
HGNC ID
HGNC:11107
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1485
ORF Size (bp)
1485 bp
Protein Name (eCommerce)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
RefSeq ID
NM_001098426
RefSeq Synonyms
NM_001330440, NM_001330439, NM_001098426, BC142963, BC136322,
Research Areas
Cancer,Chromatin Remodeling,Prostate Cancer,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. SMARCD2/BAF60B was isolated from a cDNA library in a search for proteins similar to mouse BAF60A which was identified as the paralog of the S. cerevisiae SWI/SNF component, SWP73.
UniGene ID
Hs.250581
UniProt ID (eCommerce)
Q92925

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.