human SMAD5 shRNA silencing AAV

Name
AAV-h-SMAD5-shRNA

Cat No
shAAV-223693

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SMAD5.

shAAV-223693

AAV-h-SMAD5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMAD5 (SMAD family member 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DWFC; JV5-1; MADH5

Description (Vector)

SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Gene ID

4090

Gene Name (Vector)

SMAD family member 5

Gene Symbol

SMAD5

HGNC ID

HGNC:6771

ORF Size (aa)

1398

ORF Size (bp)

1398 bp

RefSeq ID

NM_001001419

RefSeq Synonyms

NM_005903, NM_001001420, NM_001001419, BC009682,

Species

human

UniGene ID

Hs.167700

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.