human SMAD1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SMAD1.
shAAV-223688
AAV-h-SMAD1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SMAD1 (SMAD family member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1
Description (Vector)
SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Gene ID
4086
Gene Name (Vector)
SMAD family member 1
Gene Symbol
SMAD1
HGNC ID
HGNC:6767
ORF Size (aa)
1398
ORF Size (bp)
1398 bp
RefSeq ID
NM_005900
RefSeq Synonyms
NM_005900, NM_001003688, BC001878,
Species
human
UniGene ID
Hs.604588
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.