human SLC6A15 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SLC6A15.
shAAV-223559
AAV-h-SLC6A15-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SLC6A15 (solute carrier family 6 member 15). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
homolog of rat orphan transporter v7-3; hv7-3; NTT73; orphan sodium- and chloride-dependent neurotransmitter transporter NTT73; orphan transporter v7-3; SBAT1; sodium- and chloride-dependent neurotransmitter transporter NTT73; sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7; sodium-coupled branched-chain amino-acid transporter 1; sodium-dependent neutral amino acid transporter B(0)AT2; solute carrier family 6 (neurotransmitter transporter), member 15; solute carrier family 6 (neutral amino acid transporter), member 15; Solute carrier family 6 member 15; transporter v7-3; V7-3
Description (eCommerce)
SLC6A15 functions as a sodium-dependent neutral amino acid transporter. It exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. SLC6A15 mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. It may have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, SLC6A15 does not appear to be chloride-dependent [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2J7].
Description (Vector)
SLC6A15 encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
55117
Gene Name (eCommerce)
solute carrier family 6 member 15
Gene Name (Vector)
solute carrier family 6 member 15
Gene Symbol
SLC6A15
HGNC ID
HGNC:13621
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2193
ORF Size (bp)
2193 bp
Protein Name (eCommerce)
Sodium-dependent neutral amino acid transporter B(0)AT2
RefSeq ID
NM_018057
RefSeq Synonyms
NM_182767, NM_018057, NM_001146335, BC070040,
Research Areas
Neurobiology,Transport
Research Areas (Faceted)
neurobiology,cell_biology
Species
human
Target Sentence
SLC6A15 functions as a sodium-dependent neutral amino acid transporter. It exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. SLC6A15 mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. It may have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, SLC6A15 does not appear to be chloride-dependent [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2J7].
UniGene ID
Hs.44424
UniProt ID (eCommerce)
Q9H2J7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.