human SLC20A2 shRNA silencing AAV

Name 
AAV-h-SLC20A2-shRNA
Cat No 
shAAV-223174
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SLC20A2.

shAAV-223174
AAV-h-SLC20A2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC20A2 (solute carrier family 20 member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; gibbon ape leukemia virus receptor 2; GLVR2; GLVR-2; hPit2; IBGC1; IBGC3; MLVAR; murine leukemia virus, amphotropic; murine leukemia virus, amphotropic, receptor for; Phosphate transporter 2; PIT2; PIT-2; RAM1; Ram-1; receptor; sodium-dependent phosphate transporter 2; solute carrier family 20 (phosphate transporter), member 2; Solute carrier family 20 member 2
Description (eCommerce)
SLC20A2 is a sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. SLC20A2 functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q08357].
Description (Vector)
SLC20A2 encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
6575
Gene Name (eCommerce)
solute carrier family 20 member 2
Gene Name (Vector)
solute carrier family 20 member 2
Gene Symbol
SLC20A2
HGNC ID
HGNC:10947
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1959
ORF Size (bp)
1959 bp
Protein Name (eCommerce)
Sodium-dependent phosphate transporter 2
RefSeq ID
NM_006749
RefSeq Synonyms
NM_006749, NM_001257181, NM_001257180, BC028600,
Research Areas
Host-Virus Interactions,Transport
Research Areas (Faceted)
infectious_disease,cell_biology
Species
human
Target Sentence
SLC20A2 is a sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. SLC20A2 functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q08357].
UniGene ID
Hs.653173
UniProt ID (eCommerce)
Q08357

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.