human SIAH1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SIAH1.
shAAV-222980
AAV-h-SIAH1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SIAH1 (siah E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SIAH1A
Description (Vector)
SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Gene ID
6477
Gene Name (Vector)
siah E3 ubiquitin protein ligase 1
Gene Symbol
SIAH1
HGNC ID
HGNC:10857
ORF Size (aa)
942
RefSeq ID
NM_003031
RefSeq Synonyms
NM_003031, NM_001006610, BC044920, BC042550, BC035562,
Species
human
UniGene ID
Hs.295923
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.