human SHPK shRNA silencing AAV

Name
AAV-h-SHPK-shRNA

Cat No
shAAV-222960

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SHPK.

shAAV-222960

AAV-h-SHPK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SHPK (sedoheptulokinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

carbohydrate kinase-like protein; CARKL; sedoheptulokinase; SHK

Description (eCommerce)

Sedoheptulokinase (SHPK) acts as a modulator of macrophage activation through control of glucose metabolismÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHJ6].

Description (Vector)

SHPK has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements.

Gene ID

23729

Gene Name (eCommerce)

sedoheptulokinase

Gene Name (Vector)

sedoheptulokinase

Gene Symbol

SHPK

HGNC ID

HGNC:1492

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1437

ORF Size (bp)

1437 bp

Protein Name (eCommerce)

Sedoheptulokinase

RefSeq ID

NM_013276

RefSeq Synonyms

NM_013276, BC020543,

Research Areas

Immunology,Interleukin Signaling,Metabolism/Metabolic Process,Signal Transduction

Research Areas (Faceted)

cell_biology,immunology,metabolism,signal_transduction

Species

human

Target Sentence

Sedoheptulokinase (SHPK) acts as a modulator of macrophage activation through control of glucose metabolismÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHJ6].

UniGene ID

Hs.579217

UniProt ID (eCommerce)

Q9UHJ6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.