human SFRS18 shRNA silencing AAV

Name
AAV-h-SFRS18-shRNA

Cat No
shAAV-222799

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PNISR.

shAAV-222799

AAV-h-SFRS18-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PNISR (PNN interacting serine and arginine rich protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

69

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

arginine/serine-rich protein PNISR; bA98I9.2; C6orf111; HSPC306; PNN-interacting serine/arginine-rich protein; Serine/arginine-rich-splicing regulatory protein 130; serine-arginine-rich-splicing regulatory protein 130; SFRS18; splicing factor, arginine/serine-rich 130; splicing factor, arginine/serine-rich 18; SR-related protein; SR-rich protein; SRrp130

Description (eCommerce)

SFRS18/SRrp130 (splicing factor arginine/serine-rich 18) is a putative alternative splicing factor. It was identified as a factor that interacts with pinin (Pnn/DRS/memA), a cell-adhesion and nuclear protein of corneal epithelial cells. SFRS18/SRrp130 bears multiple arginine/serine-rich repeats found among the SR-related family of pre-mRNA processing factors. SFRS18/SRrp130 and pinin co-localize and are distributed as nuclear specks that correspond to the pre-splicing machinery.

Gene ID

25957

Gene Name (eCommerce)

PNN interacting serine and arginine rich protein

Gene Name (Vector)

PNN interacting serine and arginine rich protein

Gene Symbol

PNISR

HGNC ID

HGNC:21222

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2418

ORF Size (bp)

2418 bp

Protein Name (eCommerce)

Arginine/serine-rich protein PNISR

RefSeq ID

NM_032870

RefSeq Synonyms

NM_032870, NM_015491, NM_001322419, NM_001322418, NM_001322417, NM_001322416, NM_001322415, NM_001322414, NM_001322413, NM_001322412, NM_001322410, NM_001322408, NM_001322406, NM_001322405, BC172321,

Research Areas

RNA Processing

Research Areas (Faceted)

cell_biology,genetics,transcription_translation

Species

human

Target Sentence

SFRS18/SRrp130 (splicing factor arginine/serine-rich 18) is a putative alternative splicing factor. It was identified as a factor that interacts with pinin (Pnn/DRS/memA), a cell-adhesion and nuclear protein of corneal epithelial cells. SFRS18/SRrp130 bears multiple arginine/serine-rich repeats found among the SR-related family of pre-mRNA processing factors. SFRS18/SRrp130 and pinin co-localize and are distributed as nuclear specks that correspond to the pre-splicing machinery.

UniGene ID

Hs.520287

UniProt ID (eCommerce)

Q8TF01

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.