human SAV1 shRNA silencing AAV

Name
AAV-h-SAV1-shRNA

Cat No
shAAV-222278

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SAV1.

shAAV-222278

AAV-h-SAV1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SAV1 (salvador family WW domain containing protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SAV; WW45; WWP4

Description (Vector)

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Gene ID

60485

Gene Name (Vector)

salvador family WW domain containing protein 1

Gene Symbol

SAV1

HGNC ID

HGNC:17795

ORF Size (aa)

1152

RefSeq ID

NM_021818

RefSeq Synonyms

NM_021818, BC020537,

Species

human

UniGene ID

Hs.642842

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.