human SAG shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SAG.
shAAV-222205
AAV-h-SAG-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SAG (S-antigen visual arrestin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RP47; S-AG
Description (Vector)
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.
Gene ID
6295
Gene Name (Vector)
S-antigen visual arrestin
Gene Symbol
SAG
HGNC ID
HGNC:10521
ORF Size (aa)
1218
ORF Size (bp)
1218 bp
RefSeq ID
NM_000541
RefSeq Synonyms
NM_000541, BC156656,
Species
human
UniGene ID
Hs.32721
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.