human RRM2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RRM2.
shAAV-222003
AAV-h-RRM2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RRM2 (ribonucleotide reductase regulatory subunit M2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
R2; RR2; RR2M
Description (Vector)
RRM2 encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
Gene ID
6241
Gene Name (Vector)
ribonucleotide reductase regulatory subunit M2
Gene Symbol
RRM2
HGNC ID
HGNC:10452
ORF Size (aa)
1170
ORF Size (bp)
1170 bp
RefSeq ID
NM_001034
RefSeq Synonyms
NM_001165931, NM_001034, BC030154, BC001886,
Species
human
UniGene ID
Hs.226390
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.