human RPL12 shRNA silencing AAV

Name 
AAV-h-RPL12-shRNA
Cat No 
shAAV-221571
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RPL12.

shAAV-221571
AAV-h-RPL12-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPL12 (ribosomal protein L12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
60S ribosomal protein L12; L12; large ribosomal subunit protein uL11
Description (eCommerce)
60S ribosomal protein L12 (RPL12) is a ribosomal protein that is a component of the 60S subunit. RPL12 belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. RPL12 binds directly to the 26S rRNA [taken from NCBI Entrez Gene (Gene ID: 6136)].
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6136
Gene Name (eCommerce)
ribosomal protein L12
Gene Name (Vector)
ribosomal protein L12
Gene Symbol
RPL12
HGNC ID
HGNC:10302
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
498
Protein Name (eCommerce)
60S ribosomal protein L12
RefSeq ID
NM_000976
RefSeq Synonyms
NM_000976, BC105603, BC094831, BC059950, BC050644,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,RNA Binding,RNA Processing,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,transcription_translation
Species
human
Target Sentence
60S ribosomal protein L12 (RPL12) is a ribosomal protein that is a component of the 60S subunit. RPL12 belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. RPL12 binds directly to the 26S rRNA [taken from NCBI Entrez Gene (Gene ID: 6136)].
UniGene ID
Hs.408054
UniProt ID (eCommerce)
P30050

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.