human RORC shRNA silencing AAV

Name
AAV-h-RORC-shRNA

Cat No
shAAV-221499

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RORC.

shAAV-221499

AAV-h-RORC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RORC (RAR related orphan receptor C). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR

Description (Vector)

RORC is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

6097

Gene Name (Vector)

RAR related orphan receptor C

Gene Symbol

RORC

HGNC ID

HGNC:10260

ORF Size (aa)

1557

ORF Size (bp)

1557 bp

RefSeq ID

NM_005060

RefSeq Synonyms

NM_005060, NM_001001523, BC110571, BC031554,

Species

human

UniGene ID

Hs.607993

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.