human RLTPR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CARMIL2.
shAAV-221278
AAV-h-RLTPR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CARMIL2 (capping protein regulator and myosin 1 linker 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Capping protein regulator and myosin 1 linker 2; capping protein, Arp2/3 and myosin-I linker protein 2; CARMIL2b; F-actin-uncapping protein RLTPR; IMD58; leucine rich repeat containing 16C; leucine-rich repeat-containing protein 16C; LRRC16C; RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; RGD, leucine-rich repeat, tropomodulin and proline-rich containing protein; RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein; RLTPR
Description (eCommerce)
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6F5E8].
Gene ID
146206
Gene Name (eCommerce)
capping protein regulator and myosin 1 linker 2
Gene Name (Vector)
capping protein regulator and myosin 1 linker 2
Gene Symbol
CARMIL2
HGNC ID
HGNC:27089
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4305
ORF Size (bp)
4305 bp
Protein Name (eCommerce)
F-actin-uncapping protein RLTPR
RefSeq ID
NM_001013838
RefSeq Synonyms
NM_001317026, NM_001013838, BC172249,
Research Areas
Cell Biology,Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6F5E8].
UniGene ID
Hs.611432
UniProt ID (eCommerce)
Q6F5E8
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.