human RELA shRNA silencing AAV

NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; NFKB3; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; p65; transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A

RelA is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD) that functions to mediate DNA binding, dimerization, nuclear localization, and inhibitor association.

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

5970

RELA proto-oncogene, NF-kB subunit

RELA proto-oncogene, NF-kB subunit

RELA

HGNC:9955

9606.0

1647

1647 bp

Transcription factor p65

NM_021975

NM_021975, NM_001243985, NM_001243984, NM_001145138, BC110830, BC033522, BC014095,

Aging,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,Cell Cycle,Cytokine Signaling,EGFR Signaling,Fc Receptor Signaling,Gene Expression,Helicase Activity,HIF-1 Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,Notch Signaling,Phospho-specific,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,RANKL-RANK Signaling,Response to Virus,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,TSLP Signaling,TWEAK Signaling,Viral Carcinogenesis

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

human

RelA is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD) that functions to mediate DNA binding, dimerization, nuclear localization, and inhibitor association.

Hs.502875

Q04206