human RDH12 shRNA silencing AAV

Name
AAV-h-RDH12-shRNA

Cat No
shAAV-220964

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RDH12.

shAAV-220964

AAV-h-RDH12-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RDH12 (retinol dehydrogenase 12 (all-trans/9-cis/11-cis)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LCA13; RP53; SDR7C2

Description (Vector)

RDH12 is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).

Gene ID

145226

Gene Name (Vector)

retinol dehydrogenase 12 (all-trans/9-cis/11-cis)

Gene Symbol

RDH12

HGNC ID

HGNC:19977

ORF Size (aa)

951

RefSeq ID

NM_152443

RefSeq Synonyms

NM_152443, BC025724,

Species

human

UniGene ID

Hs.415322

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.