human RBP3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RBP3.
shAAV-220917
AAV-h-RBP3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RBP3 (retinol binding protein 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D10S64; D10S65; D10S66; IRBP; RBPI; RP66
Description (Vector)
Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.
Gene ID
5949
Gene Name (Vector)
retinol binding protein 3
Gene Symbol
RBP3
HGNC ID
HGNC:9921
ORF Size (aa)
3744
ORF Size (bp)
3744 bp
RefSeq ID
NM_002900
RefSeq Synonyms
NM_002900, BC039844,
Species
human
UniGene ID
Hs.591928
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.