human RAD51 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RAD51.
shAAV-220643
AAV-h-RAD51-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RAD51 (RAD51 recombinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BRCC5; FANCR; HRAD51; HsRad51; HsT16930; MRMV2; RAD51A; RECA
Description (Vector)
RAD51 is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
5888
Gene Name (Vector)
RAD51 recombinase
Gene Symbol
RAD51
HGNC ID
HGNC:9817
ORF Size (aa)
729
RefSeq ID
NM_002875
RefSeq Synonyms
NM_133487, NM_002875, NM_001164270, NM_001164269, BC001459,
Species
human
UniGene ID
Hs.631709
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.