human RAB7A shRNA silencing AAV

Name
AAV-h-RAB7A-shRNA

Cat No
shAAV-220589

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RAB7A.

shAAV-220589

AAV-h-RAB7A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RAB7A (RAB7A, member RAS oncogene family). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PRO2706; RAB7

Description (Vector)

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.

Gene ID

7879

Gene Name (Vector)

RAB7A, member RAS oncogene family

Gene Symbol

RAB7A

HGNC ID

HGNC:9788

ORF Size (aa)

624

RefSeq ID

NM_004637

RefSeq Synonyms

NM_004637, BC013728, BC008721,

Species

human

UniGene ID

Hs.716392

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.