human PTPRT shRNA silencing AAV

Name
AAV-h-PTPRT-shRNA

Cat No
shAAV-220363

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PTPRT.

shAAV-220363

AAV-h-PTPRT-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPRT (protein tyrosine phosphatase, receptor type T). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

RPTPrho

Description (Vector)

PTPRT is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Gene ID

11122

Gene Name (Vector)

protein tyrosine phosphatase, receptor type T

Gene Symbol

PTPRT

HGNC ID

HGNC:9682

ORF Size (aa)

4383

ORF Size (bp)

4383 bp

RefSeq ID

NM_007050

RefSeq Synonyms

NM_133170, NM_007050, BC166683, BC153300,

Species

human

UniGene ID

Hs.526879

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.