human PTPRB shRNA silencing AAV

Cat. No: shAAV-220334

Availability: 4-5 weeks

Name: AAV-h-PTPRB-shRNA

This is an AAV expressing shRNA for silencing of Human PTPRB.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PTPRB
Gene Name: protein tyrosine phosphatase, receptor type B
Gene ID: 5787
Gene Synonyms: HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP
ORF Size: 5994 bp
RefSeq#: NM_002837
Gene Description: PTPRB is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.434375
HGNC ID: HGNC:9665