human PTPN21 shRNA silencing AAV

Name
AAV-h-PTPN21-shRNA

Cat No
shAAV-220319

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PTPN21.

shAAV-220319

AAV-h-PTPN21-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPN21 (protein tyrosine phosphatase, non-receptor type 21). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PTPD1; PTPRL10

Description (Vector)

PTPN21 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.

Gene ID

11099

Gene Name (Vector)

protein tyrosine phosphatase, non-receptor type 21

Gene Symbol

PTPN21

HGNC ID

HGNC:9651

ORF Size (aa)

3525

ORF Size (bp)

3525 bp

RefSeq ID

NM_007039

RefSeq Synonyms

NM_007039, BC167856,

Species

human

UniGene ID

Hs.437040

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.