human PSENEN shRNA silencing AAV

Name 
AAV-h-PSENEN-shRNA
Cat No 
shAAV-220069
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PSENEN.

shAAV-220069
AAV-h-PSENEN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PSENEN (presenilin enhancer gamma-secretase subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MDS033; MSTP064; PEN-2; PEN2
Description (Vector)
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Gene ID
55851
Gene Name (Vector)
presenilin enhancer gamma-secretase subunit
Gene Symbol
PSENEN
HGNC ID
HGNC:30100
ORF Size (aa)
306
RefSeq ID
NM_172341
RefSeq Synonyms
NM_172341, NM_001281532, BC009575,
Species
human
UniGene ID
Hs.534465

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.