human PSEN1 shRNA silencing AAV

Cat. No: shAAV-220067

Availability: 4-5 weeks

Name: AAV-h-PSEN1-shRNA

This is an AAV expressing shRNA for silencing of Human PSEN1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PSEN1
Gene Name: presenilin 1
Gene ID: 5663
Gene Synonyms: AD3; FAD; PS-1; PS1; S182
ORF Size: 1392 bp
RefSeq#: NM_000021
Gene Description: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
UniGene ID: Hs.3260
HGNC ID: HGNC:9508