human UBAP1 shRNA silencing AAV

Name 
AAV-h-UBAP1-shRNA
Cat No 
shAAV-219916
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UBAP1.

shAAV-219916
AAV-h-UBAP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBAP1 (ubiquitin associated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
79
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
NAG20; nasopharyngeal carcinoma-associated gene 20 protein; UAP; UBAP; UBAP-1; ubiquitin-associated protein 1
Description (eCommerce)
Ubiquitin-associated protein 1 (UBAP1) is a component of the ESCRT-I complex, a regulator of vesicular trafficking process. It binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). It plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZ09].
Description (Vector)
UBAP1 is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
51271
Gene Name (eCommerce)
ubiquitin associated protein 1
Gene Name (Vector)
ubiquitin associated protein 1
Gene Symbol
UBAP1
HGNC ID
HGNC:12461
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1509
ORF Size (bp)
1509 bp
Protein Name (eCommerce)
Ubiquitin-associated protein 1
RefSeq ID
NM_016525
RefSeq Synonyms
NM_016525, NM_001171204, NM_001171203, NM_001171202, NM_001171201, BC100668, BC099726, BC098316, BC098141, BC020950,
Research Areas
Cell Biology,Translational Control,Transport
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Ubiquitin-associated protein 1 (UBAP1) is a component of the ESCRT-I complex, a regulator of vesicular trafficking process. It binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). It plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZ09].
UniGene ID
Hs.268963
UniProt ID (eCommerce)
Q9NZ09

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.