human PRKRIR shRNA silencing AAV

Name
AAV-h-PRKRIR-shRNA

Cat No
shAAV-219879

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human THAP12.

shAAV-219879

AAV-h-PRKRIR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human THAP12 (THAP domain containing 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

52 kDa repressor of the inhibitor of the protein kinase; 58 kDa interferon-induced protein kinase-interacting protein; DAP4; death-associated protein 4; inhibitor of protein kinase PKR; P52rIPK; p58IPK-interacting protein; P58IPK-regulatory protein; PRKRIR; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor); testicular tissue protein Li 133; THAP domain-containing protein 0; THAP domain-containing protein 12; THAP0

Description (eCommerce)

P58IPK is an inhibitor of the serine/threonine protein kinase, PKR. P58IPK functions to repress eukaryotic initiation factor 2-alpha subunit (eIF-2alpha) phosphorylation by PKR. PRKRIR, also designated P52RIPK, is a P58IPK interacting protein that abrogates P58IPK mediated suppression of PKR activity.

Gene ID

5612

Gene Name (eCommerce)

THAP domain containing 12

Gene Name (Vector)

THAP domain containing 12

Gene Symbol

THAP12

HGNC ID

HGNC:9440

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2286

ORF Size (bp)

2286 bp

Protein Name (eCommerce)

52 kDa repressor of the inhibitor of the protein kinase

RefSeq ID

NM_004705

RefSeq Synonyms

NM_004705, BC117140, BC117138, BC110304,

Research Areas

Cell Biology,Signal Transduction,Zinc-finger

Research Areas (Faceted)

signal_transduction,cell_biology

Species

human

Target Sentence

P58IPK is an inhibitor of the serine/threonine protein kinase, PKR. P58IPK functions to repress eukaryotic initiation factor 2-alpha subunit (eIF-2alpha) phosphorylation by PKR. PRKRIR, also designated P52RIPK, is a P58IPK interacting protein that abrogates P58IPK mediated suppression of PKR activity.

UniGene ID

Hs.503315

UniProt ID (eCommerce)

O43422

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.