human PRKD3 shRNA silencing AAV

Name
AAV-h-PRKD3-shRNA

Cat No
shAAV-219874

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PRKD3.

shAAV-219874

AAV-h-PRKD3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRKD3 (protein kinase D3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN

Description (Vector)

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.

Gene ID

23683

Gene Name (Vector)

protein kinase D3

Gene Symbol

PRKD3

HGNC ID

HGNC:9408

ORF Size (aa)

1836

ORF Size (bp)

1836 bp

RefSeq ID

NM_005813

RefSeq Synonyms

NM_005813, BC030706,

Species

human

UniGene ID

Hs.716034

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.