human PRELP shRNA silencing AAV

Name
AAV-h-PRELP-shRNA

Cat No
shAAV-219803

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PRELP.

shAAV-219803

AAV-h-PRELP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRELP (proline and arginine rich end leucine rich repeat protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MST161; MSTP161; SLRR2A

Description (Vector)

PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.

Gene ID

5549

Gene Name (Vector)

proline and arginine rich end leucine rich repeat protein

Gene Symbol

PRELP

HGNC ID

HGNC:9357

ORF Size (aa)

1149

ORF Size (bp)

1149 bp

RefSeq ID

NM_002725

RefSeq Synonyms

NM_201348, NM_002725, BC032498,

Species

human

UniGene ID

Hs.632481

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.