human PRELP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PRELP.
shAAV-219803
AAV-h-PRELP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PRELP (proline and arginine rich end leucine rich repeat protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MST161; MSTP161; SLRR2A
Description (Vector)
PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.
Gene ID
5549
Gene Name (Vector)
proline and arginine rich end leucine rich repeat protein
Gene Symbol
PRELP
HGNC ID
HGNC:9357
ORF Size (aa)
1149
ORF Size (bp)
1149 bp
RefSeq ID
NM_002725
RefSeq Synonyms
NM_201348, NM_002725, BC032498,
Species
human
UniGene ID
Hs.632481
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.