human PRDM1 shRNA silencing AAV

Name 
AAV-h-PRDM1-shRNA
Cat No 
shAAV-219746
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PRDM1.

shAAV-219746
AAV-h-PRDM1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRDM1 (PR/SET domain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP1; BLIMP-1; B-lymphocyte-induced maturation protein 1; Positive regulatory domain I-binding factor 1; PR domain 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI-BF1; PRDI-binding factor 1; PRDI-binding factor-1
Description (eCommerce)
PDRM1, aka Blimp-1, is a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. PDRM1 binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter and acts as a repressor of beta-interferon gene expression. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75626].
Description (Vector)
PRDM1 encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
Gene ID
639
Gene Name (eCommerce)
PR/SET domain 1
Gene Name (Vector)
PR/SET domain 1
Gene Symbol
PRDM1
HGNC ID
HGNC:9346
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2076
ORF Size (bp)
2076 bp
Protein Name (eCommerce)
PR domain zinc finger protein 1
RefSeq ID
NM_001198
RefSeq Synonyms
NM_182907, NM_001198, BC103835, BC103834, BC103833, BC103832,
Research Areas
Gene Expression,Immunology,Interleukin Signaling,Methyltransferase,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
PDRM1, aka Blimp-1, is a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. PDRM1 binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter and acts as a repressor of beta-interferon gene expression. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75626].
UniGene ID
Hs.436023
UniProt ID (eCommerce)
O75626

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.