human PRCP shRNA silencing AAV

Name
AAV-h-PRCP-shRNA

Cat No
shAAV-219745

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PRCP.

shAAV-219745

AAV-h-PRCP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRCP (prolylcarboxypeptidase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HUMPCP; PCP

Description (Vector)

PRCP is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene ID

5547

Gene Name (Vector)

prolylcarboxypeptidase

Gene Symbol

PRCP

HGNC ID

HGNC:9344

ORF Size (aa)

1491

ORF Size (bp)

1491 bp

RefSeq ID

NM_005040

RefSeq Synonyms

NM_199418, NM_005040, NM_001319214, BC001500,

Species

human

UniGene ID

Hs.523936

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.