human PPP2R5D shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PPP2R5D.
shAAV-219669
AAV-h-PPP2R5D-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PPP2R5D (protein phosphatase 2 regulatory subunit B’delta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B56D; B56delta; MRD35; PP2A B subunit isoform B56-delta; PP2A B subunit isoform B'-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; protein phosphatase 2, regulatory subunit B (B56), delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Description (eCommerce)
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R5D is a regulatory subunit of PP2A. The regulatory subunits of PP2A are grouped into 3 families: B/PR55, B’/PR61, and B’’/PR72. PPP2R5D encodes the delta isoform of the B’ subunit, B56. PPP2R5D may function to localize PP2A to the nucleus. serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, PP2A B subunit B’ delta isoform, PP2A B subunit B56 delta isoform, PP2A B subunit PR61 delta isoform, PP2A B subunit R5 delta isoform, B56D, MGC2134, MGC8949.
Description (Vector)
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
5528
Gene Name (eCommerce)
protein phosphatase 2 regulatory subunit B'delta
Gene Name (Vector)
protein phosphatase 2 regulatory subunit B'delta
Gene Symbol
PPP2R5D
HGNC ID
HGNC:9312
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1713
ORF Size (bp)
1713 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
RefSeq ID
NM_006245
RefSeq Synonyms
NM_180977, NM_180976, NM_006245, NM_001270476, BC010692, BC001175, BC001095,
Research Areas
Alzheimer's Disease,Cell Cycle,GPCR Signaling,Immunology,Innate Immunity,Kinase/Phosphatase,MAPK Signaling,Meiosis,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,Neurodegeneration,Neurodevelopment,NGF Signaling,Notch Signaling,PI3K/Akt Signaling,Signal Transduction,Toll-like Receptor Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R5D is a regulatory subunit of PP2A. The regulatory subunits of PP2A are grouped into 3 families: B/PR55, B’/PR61, and B’’/PR72. PPP2R5D encodes the delta isoform of the B’ subunit, B56. PPP2R5D may function to localize PP2A to the nucleus. serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, PP2A B subunit B’ delta isoform, PP2A B subunit B56 delta isoform, PP2A B subunit PR61 delta isoform, PP2A B subunit R5 delta isoform, B56D, MGC2134, MGC8949.
UniGene ID
Hs.533308
UniProt ID (eCommerce)
Q14738
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.