human PPIA shRNA silencing AAV

Name
AAV-h-PPIA-shRNA

Cat No
shAAV-219541

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PPIA.

shAAV-219541

AAV-h-PPIA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PPIA (peptidylprolyl isomerase A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CYPA; CYPH; HEL-S-69p

Description (Vector)

PPIA encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

Gene ID

5478

Gene Name (Vector)

peptidylprolyl isomerase A

Gene Symbol

PPIA

HGNC ID

HGNC:9253

ORF Size (aa)

318

RefSeq ID

NM_021130

RefSeq Synonyms

NM_021130, NM_001300981, BC137058, BC137057, BC106030, BC093076, BC073992, BC013915, BC007104, BC005982, BC005320, BC003026, BC000689,

Species

human

UniGene ID

Hs.598115

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.