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human POT1 shRNA silencing AAV

Name 
AAV-h-POT1-shRNA
Cat No 
shAAV-219457
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human POT1.

shAAV-219457
AAV-h-POT1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POT1 (protection of telomeres 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CMM10; GLM9; HPOT1
Description (Vector)
POT1 is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
Gene ID
25913
Gene Name (Vector)
protection of telomeres 1
Gene Symbol
POT1
HGNC ID
HGNC:17284
ORF Size (aa)
1905
ORF Size (bp)
1905 bp
RefSeq ID
NM_015450
RefSeq Synonyms
NM_015450, NM_001042594, BC002923,
Species
human
UniGene ID
Hs.31968

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.