human POLE4 shRNA silencing AAV

Name
AAV-h-POLE4-shRNA

Cat No
shAAV-219363

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human POLE4.

shAAV-219363

AAV-h-POLE4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POLE4 (DNA polymerase epsilon 4, accessory subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

p12; YHHQ1

Description (Vector)

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.(supplied by OMIM, Apr 2004)

Gene ID

56655

Gene Name (Vector)

DNA polymerase epsilon 4, accessory subunit

Gene Symbol

POLE4

HGNC ID

HGNC:18755

ORF Size (aa)

354

RefSeq ID

NM_019896

RefSeq Synonyms

NM_019896, BC031331,

Species

human

UniGene ID

Hs.469060

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.