human POLE3 shRNA silencing AAV

Name 
AAV-h-POLE3-shRNA
Cat No 
shAAV-219361
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human POLE3.

shAAV-219361
AAV-h-POLE3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POLE3 (DNA polymerase epsilon 3, accessory subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
arsenic transactivated protein; Arsenic-transactivated protein; asTP; CHARAC17; CHRAC17; CHRAC-17; CHRAC2; chromatin accessibility complex 17 kDa protein; chromatin accessibility complex subunit 2; DNA polymerase epsilon p17 subunit; DNA polymerase epsilon subunit 3; DNA polymerase epsilon subunit p17; DNA polymerase II subunit 3; histone fold protein CHRAC17; huCHRAC17; p17; polymerase (DNA directed), epsilon 3 (p17 subunit); polymerase (DNA directed), epsilon 3, accessory subunit; polymerase (DNA) epsilon 3, accessory subunit; YBL1
Description (eCommerce)
PolE3/p17 is a subunit of DNA polymerase epsilon that plays a role in DNA replication and repair. PolE3/p17 contains histone-fold motifs which play a role in protein-protein and protein-DNA interactions. PolE3/p17 interacts with CHRAC1 (chromatin assembly complex 1), ACF1, and ISWI/SNF2H proteins to form the CHRAC ISWI chromatin-remodeling complex.
Description (Vector)
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.(supplied by OMIM, Apr 2004)
Gene ID
54107
Gene Name (eCommerce)
DNA polymerase epsilon 3, accessory subunit
Gene Name (Vector)
DNA polymerase epsilon 3, accessory subunit
Gene Symbol
POLE3
HGNC ID
HGNC:13546
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
444
Protein Name (eCommerce)
DNA polymerase epsilon subunit 3
RefSeq ID
NM_017443
RefSeq Synonyms
NM_017443, NM_001278255, BC004170, BC003166,
Research Areas
DNA Damage/Repair,DNA Replication,Histone Modification,Host-Virus Interactions,Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,transcription_translation
Species
human
Target Sentence
PolE3/p17 is a subunit of DNA polymerase epsilon that plays a role in DNA replication and repair. PolE3/p17 contains histone-fold motifs which play a role in protein-protein and protein-DNA interactions. PolE3/p17 interacts with CHRAC1 (chromatin assembly complex 1), ACF1, and ISWI/SNF2H proteins to form the CHRAC ISWI chromatin-remodeling complex.
UniGene ID
Hs.108112
UniProt ID (eCommerce)
Q9NRF9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.