human POLD4 shRNA silencing AAV

Name
AAV-h-POLD4-shRNA

Cat No
shAAV-219350

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human POLD4.

shAAV-219350

AAV-h-POLD4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POLD4 (DNA polymerase delta 4, accessory subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

p12; POLDS

Description (Vector)

POLD4 encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

57804

Gene Name (Vector)

DNA polymerase delta 4, accessory subunit

Gene Symbol

POLD4

HGNC ID

HGNC:14106

ORF Size (aa)

324

RefSeq ID

NM_021173

RefSeq Synonyms

NM_021173, NM_001256870, BC070250, BC001334,

Species

human

UniGene ID

Hs.523829

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.