human PMP22 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PMP22.
shAAV-219274
AAV-h-PMP22-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PMP22 (peripheral myelin protein 22). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMT1A; CMT1E; DSS; GAS-3; GAS3; HMSNIA; HNPP; Sp110
Description (Vector)
PMP22 encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing of this gene results in three transcript variants that encode the same protein.
Gene ID
5376
Gene Name (Vector)
peripheral myelin protein 22
Gene Symbol
PMP22
HGNC ID
HGNC:9118
ORF Size (aa)
483
RefSeq ID
NM_000304
RefSeq Synonyms
NM_153322, NM_153321, NM_001330143, NM_001281456, NM_001281455, NM_000304, BC091499, BC019040,
Species
human
UniGene ID
Hs.372031
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.