human PLAT shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PLAT.
shAAV-219106
AAV-h-PLAT-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PLAT (plasminogen activator, tissue type). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
T-PA; TPA
Description (Vector)
PLAT encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Gene ID
5327
Gene Name (Vector)
plasminogen activator, tissue type
Gene Symbol
PLAT
HGNC ID
HGNC:9051
ORF Size (aa)
1551
ORF Size (bp)
1551 bp
RefSeq ID
NM_000930
RefSeq Synonyms
NM_033011, NM_001319189, NM_000930, BC095403, BC018636, BC013968, BC007231, BC002795,
Species
human
UniGene ID
Hs.491582
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.