human PKP2 shRNA silencing AAV

Name 
AAV-h-PKP2-shRNA
Cat No 
shAAV-219046
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PKP2.

shAAV-219046
AAV-h-PKP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PKP2 (plakophilin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARVD9
Description (Vector)
PKP2 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. PKP2 product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.
Gene ID
5318
Gene Name (Vector)
plakophilin 2
Gene Symbol
PKP2
HGNC ID
HGNC:9024
ORF Size (aa)
2514
ORF Size (bp)
2514 bp
RefSeq ID
NM_004572
RefSeq Synonyms
NM_004572, NM_001005242, BC143966, BC126199, BC094762,
Species
human
UniGene ID
Hs.164384

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.