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human PIK3R4 shRNA silencing AAV

Name 
AAV-h-PIK3R4-shRNA
Cat No 
shAAV-218960
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PIK3R4.

shAAV-218960
AAV-h-PIK3R4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
p150; phosphatidylinositol 3-kinase-associated p150; phosphoinositide 3-kinase adaptor protein; phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; VPS15
Description (eCommerce)
VPS (vacuolar protein sorting) proteins were originally characterized and studied in the yeast model and found to play a critical role in vesicle-mediated sorting of proteins to lysosome-like vacuoles. The human homolog of the yeast Vps15 protein was identified as a 150 kDa cellular protein that associates with the phosphatidylinositol (PtdIns) 3 kinase, Vps34p. Vps15 is a serine/threonine protein kinase that associates in a complex with beclin 1 and plays an important role in autophagy.
Gene ID
30849
Gene Name (eCommerce)
phosphoinositide-3-kinase regulatory subunit 4
Gene Name (Vector)
phosphoinositide-3-kinase regulatory subunit 4
Gene Symbol
PIK3R4
HGNC ID
HGNC:8982
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4077
ORF Size (bp)
4077 bp
Protein Name (eCommerce)
Phosphoinositide 3-kinase regulatory subunit 4
RefSeq ID
NM_014602
RefSeq Synonyms
NM_014602, BC127106, BC127105, BC110318,
Research Areas
Autophagy,Cytoskeleton,Golgi Apparatus,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Kinase/Phosphatase,Metabolism/Metabolic Process,Signal Transduction,Toll-like Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,metabolism,signal_transduction
Species
human
Target Sentence
VPS (vacuolar protein sorting) proteins were originally characterized and studied in the yeast model and found to play a critical role in vesicle-mediated sorting of proteins to lysosome-like vacuoles. The human homolog of the yeast Vps15 protein was identified as a 150 kDa cellular protein that associates with the phosphatidylinositol (PtdIns) 3 kinase, Vps34p. Vps15 is a serine/threonine protein kinase that associates in a complex with beclin 1 and plays an important role in autophagy.
UniGene ID
Hs.149032
UniProt ID (eCommerce)
Q99570

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.