human PICK1 shRNA silencing AAV

Name
AAV-h-PICK1-shRNA

Cat No
shAAV-218898

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PICK1.

shAAV-218898

AAV-h-PICK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PICK1 (protein interacting with PRKCA 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PICK; PRKCABP

Description (Vector)

PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

Gene ID

9463

Gene Name (Vector)

protein interacting with PRKCA 1

Gene Symbol

PICK1

HGNC ID

HGNC:9394

ORF Size (aa)

1248

ORF Size (bp)

1248 bp

RefSeq ID

NM_012407

RefSeq Synonyms

NM_012407, NM_001039584, NM_001039583, BC017561,

Species

human

UniGene ID

Hs.180871

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.